7,086 research outputs found
Secuelas tras inyecciĂłn ilegal de silicona lĂquida como tĂŠcnica de aumento mamario: presentaciĂłn de 2 casos
The use of liquid silicone for breast augmentation
was widespread in the 1960s but was abandoned at
the end of the decade due to numerous studies describing
the development of a large number of local
complications, as well as remote migration of small
amounts of silicone. The use of liquid silicone also leads
to enormous difficulty in the early diagnosis of
breast cancer; these patients are precluded from routine
screening programs and must undergo exhaustive
periodic examinations. Magnetic resonance imaging
has become the most effective test for the early
detection of breast cancer in these patients. Indications
for subcutaneous mastectomy are the presence
of local complications, suspicion of a malignant lesion,
or the patientâs desire to prevent both these potential
problems
A completely phased diploid genome assembly for "Malbec" cultivar (Vitis vinifera L.)
Most grapevine cultivars originated from the outcrossing of two genetically diverse parents, and are clonally propagated to preserve phenotypes of productive interest. Hence, cultivars are first filial generations (F1) with highly heterozygous diploid genomes, that turn challenging to assemble. "Malbec" is the main cultivar for the Argentine wine industry and it originated in France, from the outcrossing of Magdeleine Noir des Charentes and Prunelard cultivars. Based on that mother-father-offspring relationship, here we followed the algorithm implemented in the software CanuTrio to produce a phased assembly of Malbec genome. For this aim, parental cultivars? Illumina short-reads were used to sort ?Malbec? PacBio long-reads into its haploid complements, to be assembled separately. Post- assembly, bioinformatic procedures were employed to reduce the number of duplicated regions and perform sequence error corrections (using Malbec Illumina short-reads). We obtained two highly complete and contiguous haploid assemblies for Malbec, Haplotype- Prunelard (482.4 Mb size; contig N50=7.7 Mb) and Haplotype-Magdeleine (479.4 Mb size; contig N50=6.6 Mb), with 96.1 and 95.8% of BUSCO genes, respectively. We tested for the composition of both haplophases with the tool Merqury, and observed 15% of both assemblies affected by structural variations, along with 3.2 million SNPs and 0.6 million InDels. Our results indicate that this is a valid approach to assemble highly heterozygous and complex diploid genomes in a completely-phased way.Fil: CalderĂłn, Pablo Luciano Sebastian. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de BiologĂa AgrĂcola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de BiologĂa AgrĂcola de Mendoza; ArgentinaFil: Carbonell Bejerano, P.. Max Planck Institute for Developmental Biology; AlemaniaFil: Mauri, N. Instituto de Ciencias de la Vid y del Vino; EspaĂąaFil: MuĂąoz, Claudio Javier. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de BiologĂa AgrĂcola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de BiologĂa AgrĂcola de Mendoza; ArgentinaFil: Bree, Laura. No especifĂca;Fil: Sola, C. No especifĂca;Fil: Bergamin, D. No especifĂca;Fil: GĂłmez Talquenca, SebastiĂĄn. Instituto Nacional de TecnologĂa Agropecuaria; ArgentinaFil: IbaĂąez, J. Instituto de Ciencias de la Vid y del Vino; EspaĂąaFil: Martinez-Zapater, JM. Instituto de Ciencias de la Vid y del Vino; EspaĂąaFil: Lijavetzky, Diego Claudio. Consejo Nacional de Investigaciones CientĂficas y TĂŠcnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de BiologĂa AgrĂcola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de BiologĂa AgrĂcola de Mendoza; ArgentinaXVIII Congreso Latinoamericano de GenĂŠtica; LIV ReuniĂłn Anual de la Sociedad de GenĂŠtica de Chile; XLIX Congreso Argentino de GenĂŠtica; VIII Congreso de la Sociedad Uruguaya de GenĂŠtica; I Congreso Paraguayo de GenĂŠtica y V Congreso Latinoamericano de GenĂŠtica HumanaChileSociedad Argentina de GenĂŠtic
Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation
We report a case of a 13-year-old girl with soft tissue sarcoma of the hand,
which showed muscle and neuroectodermal immunophenotypes. Molecular studies were
performed on RNA collected from fine-needle aspiration (FNA) cytology and
peripheral blood samples by nested reverse transcriptase-polymerase chain
reaction (RT-PCR) and Southern blot analysis. This biphenotypic tumor showed
simultaneous expression of EWS-FLI1 and PAX3-FKHR transcripts, specific of Ewing
family tumors and alveolar rhabdomyosarcoma, respectively. Although childhood
sarcomas with simultaneous muscle and neural differentiation have been described
to have EWS-FLI1 transcripts, there are no reports of tumors with both
transcripts. Cytological specimens are a good source of RNA for molecular
studie
Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER, "Otra manera de hacer Europa", "Investing in your future"); Red EspaĂąola de Esclerosis MĂşltiple (REEM - RD16/0015/0002, RD16/0015/0003, RD12/0032/0002, RD12/0060/01-02); TEVA Spain; FundaciĂłn Merck Salud (Ayudas Merck de InvestigaciĂłn 2017); Proyecto Societat Catalana Neurologia 2017; CIBERNED program (Program 1, Alzheimer Disease and SIGNAL study); National Institutes of Health (NIA grants 1R01AG056850-01A1, R21AG056974, R01AG061566;, FundaciĂł La MaratĂł de TV3 (20142030, 20141210); FundaciĂł Catalana SĂndrome de Down; FundaciĂł VĂctor GrĂfols i Lucas; Generalitat de Catalunya (SLT006/17/00119); Universitat de Barcelona (APIF Pre-doctoral grant); Hospital Clinic Emili Letang).The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients with MS classified into three groups according to disease duration. Additionally, we investigated the relationship between GM changes with disease severity. We studied 54 healthy controls and 247 MS patients classified regarding disease duration: MS1 (less than 5 years, n = 67); MS2 (5-15 years, n = 107); and MS3 (more than15 years, n = 73). We compared GM mean diffusivity (MD), fractional anisotropy (FA) and volume between groups, and estimated their clinical associations. Regional modifications in diffusion measures (MD and FA) and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in deep GM and left precuneus. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes in MD and volume extended to more than 80% of regions in MS3 group. Conversely, increments in FA, with very low effect size, were observed in the parietal cortex and thalamus in MS1 and MS2 groups, and extended to the frontal lobe in the later group. MD and GM changes were associated with white matter lesion load and with physical and cognitive disability. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage
Proprieties of FBK UFSDs after neutron and proton irradiation up to 6*10e15 neq/cm2
The properties of 60-{\mu}m thick Ultra-Fast Silicon Detectors (UFSD)
detectors manufactured by Fondazione Bruno Kessler (FBK), Trento (Italy) were
tested before and after irradiation with minimum ionizing particles (MIPs) from
a 90Sr \b{eta}-source . This FBK production, called UFSD2, has UFSDs with gain
layer made of Boron, Boron low-diffusion, Gallium, Carbonated Boron and
Carbonated. The irradiation with neutrons took place at the TRIGA reactor in
Ljubljana, while the proton irradiation took place at CERN SPS. The sensors
were exposed to a neutron fluence of 4*10e14, 8*1014, 1.5*10e15, 3*10e15,
6*10e15 neq/cm2 and to a proton fluence of 9.6*10e14 p/cm2, equivalent to a
fluence of 6*10e14 neq/cm2. The internal gain and the timing resolution were
measured as a function of bias voltage at -20C. The timing resolution was
extracted from the time difference with a second calibrated UFSD in
coincidence, using the constant fraction method for both.Comment: arXiv admin note: text overlap with arXiv:1803.0269
Tumor response assessment in locally advanced colon cancer after neoadjuvant chemotherapy
BACKGROUND:
Preoperative chemotherapy followed by radical surgery is a novel therapeutic approach for locally advanced colon cancer (LACC). Neoadjuvant strategies require highly accurate diagnostic tests for a proper selection of candidate patients, allowing a low risk of overtreatment. This paper assesses the radiological, metabolic and pathological findings induced by preoperative oxaliplatin and fluoropyrimidines-based chemotherapy in LACC.
METHODS:
Forty-four consecutive patients with a confirmed diagnosis of LACC who received neoadjuvant chemotherapy and colon surgery were included. All patients were staged at baseline and before surgery. Clinical diagnosis consisted of physical examination, endoscopy with biopsy and computed tomography (CT) scan. In selected cases, a positron emission tomography/CT (PET/CT) scan was also performed. Accuracy and correlations between CT scan findings and pathologic report was assayed for T stage, N stage and TN stage. This study is retrospective in design.
RESULTS:
After chemotherapy, a statistical significant tumor volume reduction of 62.5% was achieved by CT-scan (P<0.001; Wilcoxon test) and a 38.9% decrease of standard uptake value (SUVmax) was observed on PET/CT (P=0.004). No progressive disease was reported during neoadjuvant treatment. Accuracy for T and N classification was 62% and 87%, respectively. Accuracy for TN stage was 77%, with 13.6% and 9.1% of the patients being under or overstaged, respectively. Pathologic stage II and III disease was observed in 29/44 (65.9%) and 15/44 (34.1%) of the patients, respectively. Pathologic complete response was achieved in three patients.
CONCLUSIONS:
Oxaliplatin/fluorpyrimidine neoadjuvant chemotherapy induces major tumour shrinkage at both the pathological and radiological levels. The CT scan shows a high accuracy and a low overstaged rate in LACC patients treated by means of a neoadjuvant approach
Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in âs=13âTeV pp collisions with the ATLAS detector
A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of âs=13ââTeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139ââfbâ1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015â2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
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